{"id":1349,"date":"2020-10-20T15:21:53","date_gmt":"2020-10-20T06:21:53","guid":{"rendered":"https:\/\/www.urogynnet.jp\/?p=1349"},"modified":"2020-10-31T09:02:55","modified_gmt":"2020-10-31T00:02:55","slug":"%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e8%aa%8d%e7%9f%a5%e7%97%87%e3%81%ae%e7%b4%a0%e5%9b%a0%e3%81%ae%e3%81%82%e3%82%8b%e4%ba%ba%e3%81%8c%e6%8a%97%e3%82%b3%e3%83%aa%e3%83%b3","status":"publish","type":"post","link":"https:\/\/www.urogynnet.jp\/%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e8%aa%8d%e7%9f%a5%e7%97%87%e3%81%ae%e7%b4%a0%e5%9b%a0%e3%81%ae%e3%81%82%e3%82%8b%e4%ba%ba%e3%81%8c%e6%8a%97%e3%82%b3%e3%83%aa%e3%83%b3\/","title":{"rendered":"\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u8a8d\u77e5\u75c7\u306e\u7d20\u56e0\u306e\u3042\u308b\u4eba\u304c\u6297\u30b3\u30ea\u30f3\u85ac\u3092\u670d\u7528\u3057\u305f\u5834\u5408"},"content":{"rendered":"

Neurology\u306b\u6295\u7a3f\u3055\u308c\u305f\u8ad6\u6587\u306b\u3088\u308b\u3068\u3001\u6297\u30b3\u30ea\u30f3\u85ac\u306eMCI\u30ea\u30b9\u30af\u3001APOE \u03b54\u907a\u4f1d\u5b50\u4fdd\u6709\u8005\u3067\u5927\u304d\u3044\u3068\u5831\u3058\u3066\u3044\u308b\u3002<\/p>\n

Weigand AJ, et al. Association of anticholinergic medication and AD biomarkers with incidence of MCI among cognitively normal older adults. Neurology. 2020 Sep 2<\/p>\n

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\u6297\u30b3\u30ea\u30f3\u85ac\u306e\u8a8d\u77e5\u6a5f\u80fd\u3078\u306e\u5f71\u97ff<\/p>\n

\u304a\u3088\u3073\u3001APOE \u03b54\u907a\u4f1d\u5b50\u578b\u3068\u9ac4\u6db2\uff08CSF\uff09\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u691c\u8a0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

APOE \u03b54\u907a\u4f1d\u5b50\u3068\u306f\u3001<\/p>\n

\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7(\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5)\u306f\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u30d9\u30fc\u30bf\u30da\u30d6\u30c1\u30c9\u3068\u3044\u3046\u8001\u5ec3\u7269\u304c\u8133\u306b\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3067\u3001 \u795e\u7d4c\u7d30\u80de\u306b\u969c\u5bb3\u3092\u4e0e\u3048\u307e\u3059\u3002\u3053\u308c\u304c\u8a8d\u77e5\u75c7\u306e\u539f\u56e0\u3067\u3059\u3002\u30a2\u30df\u30ed\u30a4\u30c9\u30d9\u30fc\u30bf\u30da\u30d6\u30c1\u30c9\u306e\u84c4\u7a4d\u3084\u51dd\u96c6\u306b\u95a2\u308f\u308b\u7269\u8cea\u304c\u4f55\u7a2e\u985e\u3082\u3042\u308a\u3001\u305d\u306e\u3072\u3068\u3064\u304c\u3001\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE\u3067\u3059\u3002\u305d\u306e\u907a\u4f1d\u5b50\u3067\u3042\u308b\u3001APOE(\u30a2\u30dd\u30a4\u30fc)\u907a\u4f1d\u5b50\u306b\u306f\u3001\u4e3b\u306b\u03b5(\u30a4\u30d7\u30b7\u30ed\u30f3)2\u3001\u03b53\u3001\u03b54\u306e3\u7a2e\u985e\u3042\u308a\u3001 2\u3064\u4e00\u7d44\u3067\u907a\u4f1d\u5b50\u578b\u3092\u69cb\u6210\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306eAPOE \u03b54\u907a\u4f1d\u5b50\u3068\u3044\u3046\u306e\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u8a8d\u77e5\u75c7\u3067\u7528\u3044\u3089\u308c\u308b\u7814\u7a76\u6307\u6a19\u3067\u3059\u3002<\/p><\/blockquote>\n

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\u305d\u306e\u7d50\u679c\u3001\u6297\u30b3\u30ea\u30f3\u85ac\u4f7f\u7528\u306b\u3088\u3063\u3066\u8efd\u5ea6\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\uff08MCI\uff09\u306e\u9032\u884c\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

APOE \u03b54\u907a\u4f1d\u5b50\u4fdd\u6709\u8005\u304c\u6297\u30b3\u30ea\u30f3\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u3068\u3001APOE \u03b54\u907a\u4f1d\u5b50\u975e\u4fdd\u6709\u8005\u306e\u6297\u30b3\u30ea\u30f3\u85ac\u975e\u4f7f\u7528\u3068\u6bd4\u3079\u3066\u3001MCI\u767a\u75c7\u30ea\u30b9\u30af\u304c2\u500d\u4ee5\u4e0a\u9ad8\u304f\u306a\u3063\u305f\u3068\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8133\u810a\u9ac4\u6db2\u4e2d\u306e\u30ea\u30f3\u9178\u5316\u30bf\u30a6\u86cb\u767d\u304a\u3088\u3073\u30a2\u30df\u30ed\u30a4\u30c9\u00df\u967d\u6027\uff08p-tau\/A\u00df+\uff09\u306e\u6297\u30b3\u30ea\u30f3\u85ac\u4f7f\u7528\u306f\u3001\u3044\u305a\u308c\u3082\u9670\u6027\uff08p-tau\/A\u00df-\uff09\u306e\u6297\u30b3\u30ea\u30f3\u85ac\u975e\u4f7f\u7528\u3068\u6bd4\u3079\u3001\u30ea\u30b9\u30af\u306f4\u500d\u4ee5\u4e0a\u9ad8\u304b\u3063\u305f\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\u5965\u4e95\u306e\u89e3\u8aac\uff09<\/p>\n

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 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"Neurology\u306b\u6295\u7a3f\u3055\u308c\u305f\u8ad6\u6587\u306b\u3088\u308b\u3068\u3001\u6297\u30b3\u30ea\u30f3\u85ac\u306eMCI\u30ea\u30b9\u30af\u3001APOE \u03b54\u907a\u4f1d\u5b50\u4fdd\u6709\u8005\u3067\u5927\u304d\u3044\u3068\u5831\u3058\u3066\u3044\u308b\u3002 Weigand AJ, et al. Association of anticholinergic […]","protected":false},"author":1,"featured_media":1350,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23,21],"tags":[],"yoast_head":"\n\n\n\n\n\n\n\n\n\n\n\n\t\n\t\n\n\n\t\n